As I explained, calcium and strontium compete for absorption, and calcium will always be preferentially absorbed. In contrast, no correlation was found for the expressions of metabolizing enzymes between rat and human intestine, which indicates the difference in drug metabolism and oral bioavailability in two species. So interesting! It was impossible to calculate the elemental dosage because they didnt provide the molar-mas of the compound. Lara And truly, isnt this wonderful? I was concerned the 9.3 calcium was at the high end of normal, but am more concerned that you think it is high. Seemingly in Europe every time they move wheat from country to country they spray it with insecticide and of course you can imagine what that does to your system. That being said, your note suggests to me that if you have not already had your vitamin D levels checked, you should do so! You can get it at the following link. I expect it may not be possible for you to ask for strontium in its natural form of strontium citrate, rather than the drug form, strontium ranelate? None of the articles however, showed 170 mg to be more effective than 680 mg. Thanks for sharing and we hope you enjoy some of our other blog articles ? I have a question re. With no negative side effects. Peng S, Liu XS, Huang S, et al. Synthesis and pharmacokinetics of strontium fructose 1,6-diphosphate (Sr-FDP) as a potential anti-osteoporosis agent in intact and ovariectomized rats. CONCLUSIONS: The data indicate that rat and human show similar drug intestinal absorption profiles and similar transporter expression patterns in the small intestine, while the two species exhibit distinct expression levels and patterns for metabolizing enzymes in the intestine. So, if your patient achieves a 5% increase in BMD in their lumbar spine, when you factor out strontiums BMD overestimation, on average thats still a 4.5% increase. Hi Lara: I will be having a DEXA scan next month to determine if the strontium citrate and algae cal plus that I presently take have been effective in increasing my bone density. Heres a link to my talk on TBS: https://blog.algaecal.com/how-to-analyze-your-dexa-results-for-bone-quality/ The really good news is that your DXA images can be used to calculate your TBS, so please request that this be done for you when you go in for your next DXA. Is this a test that those of us taking strontium citrate should request of our doctors? I pulled and read the full paper. The PubMed research indicates just the opposite is true. Trabecular bone is much more metabolically active than cortical bone, so when strontium treatment is stopped, the small number of strontium ions that were exchanged for calcium ions are soon released during normal healthy bone renewal, and this results in a rapid decrease in total bone strontium levels. Were not wanting to have healthy bones just to stay above ground on the planet; as the song lyric says, Girls just want to have fun!. The citrate portion is both an alkalinizer (so helps prevent an acidic body pH, which promotes calcium withdrawal from bone / bone loss) and is also used in the Krebs cycle (a key part of the energy production cycle in our cells). Optimal levels are now considered to be 60-80 ng/mL. The volunteer was recruited in December 2008, as part of the Ryerson and McMaster University Strontium in Bone Research Study and measured at twice weekly, weekly and monthly intervals. What is the excretion of strontium citrate? A special form of strontium called strontium ranelate can increase bone formation and prevent bone loss when used in postmenopausal women with osteoporosis. I would be interested to learn of any further research on Lactoferrin and its positive effects on bone building. I understand that strontium is an element with a higher weight on the periodic table and therefore occupies more space or creates a denser appearing bone structure on a DEXA. We hope this helps! Expert Opin Drug Saf. The other night I contacted the manufacturer of my strontium and inquired as to if the supplement was better absorbed on an empty stomach or with food. "He didn't do it. Hello Lara, would you be so kind to post links to the most recent independent scientific studies and tests done on Strontium Citrate? Check your diet to see how much magnesium it provides, again, you can use the Foods Rich in Magnesium table to do so quickly if you have Your Bones. I then searched a series of database/citation indexes (e.g. In addition, the expressions of metabolizing enzymes (CYP3A4/CYP3A9 and UDPG) showed 12 to 193-fold difference between human and rat intestine with distinct regional dependent expression patterns. Taking your thyroid medication properly helps you absorb it well and limits your risk of side effects. One of strontium's isotopes Strontium-90 has a more sinister reputation. Providing them, if you are currently deficient and many people are may restore healthful thyroid function. I wish it were less complicated, and we could all just do exactly the same thing, and it would be just right for each of us but this is not how it is. Specifically based on strontium levels and safety. Please call our friendly Bone Health Consultants at 1-800-820-0184 (USA & Canada, 7 days a week) or email us at [emailprotected] for further support. To regulate my INR levels I have to be careful with vitamin k. Is strontium citrate safe for me? Hi, I have been taking calcium, calcium rich foods and exercising to keep my bones strong, but my bone density test still show low bone density in my right hip. Medical research is VERY expensive, so the drug companies are not going to spend the money on something they cannot patent and make a big profit on. Please clarify. I get ours on-line from Oregons Choice it tastes so much better than StarKist, absolutely no comparison, and while the cost per can is higher, the cans are several ounces bigger. Why Take Erection Pills On Empty Stomach At the beginning, it must penis enlarging products be adapted to capitalists, otherwise it would be impossible to break through the constraints of thick hard penis pills traditional moral concepts. Riedel C, Zimmermann EA, Zustin J, et al. Youre so welcome! Taking 1 capsule several times a day will be a bit of a hassle as you must take strontium several hours before or after consuming calcium, so it would be easier to take 2-3 at once. I believe these will be posted on AlgaeCals website soon. To all our good health Int J Clin Oncol. We have found in the more than 6,000 patients we have now tested in a health promotion project we have been involved in up in Calgary that virtually everyone needs at least 2,000 IU per day, many need 5,000 IU per day or even more.) I dont mind the small inconvenience because I know I am rebuilding my bones. Ive now heard from a number of women who find it simplest to take their strontium supplement right before going to bed so around 4 hours after their evening meal. Aquamin has no valid studies on bone health. I am a fish vegetarian so eat healthily catch the sun and walk whenever I can. Keep me posted, Lara. In one of the studies he notes, women with the lowest levels of DHEA had double the risk of fracture as women with the highest levels. When you take strontium, it will take the place of an extremely small number of calcium ions, but this tiny amount of strontium will have MANY very positive effects on your bones ability to not just rebuild, but to become more resilient and resistant to fracture. But I would strongly advise you NOT to use any dosage of this abnormal form of strontium! There was a significant reduction in the number of patients experiencing new vertebral deformities in the second year of treatment with 2 g/d SR [relative risk 0.56; 95% confidence interval (0.35; 0.89)]. Strontium ranelate the prescription drug form of strontium is associated with a very serious rash-like syndrome called DRESS syndrome, so if you were taking that, I would be telling you to head to the emergency room right away!. You should be taking both AlgaeCal Plus and their strontium product, which is called Strontium Boost (and which is strontium citrate). Re strontium the amount you are currently taking is very low! For your 3rd question, in Lara Pizzornos book Healthy Bones, Healthy You, she advises that In humans, strontium elimination from the skeleton occurs in 2 phases: an initial rapid clearancewhere 50% will be eliminated within 41 days followed by a slower phase of elimination during which the remaining half is lost over the following 3 years. Here is a link to their main website: http://www.cancercenter.com/?source=GOOGLEBR&channel=paid%20search&c=paid%20search:Google:Google%20-%20National%20Branded:Branded+Test:cancer+treatment+centers+of+america:Exact&OVMTC=Exact&site=&creative=1144020265&OVKEY=cancer%20treatment%20centers%20of%20america&url_id=129386665&adpos=1t1&gclid=CImHytX1iLUCFexxQgodlngA4g AND another link to their contact page: http://www.cancercenter.com/contact-us.cfm. I did not know that; I did take the strontium citrate shortly after eating my breakfast cereal with almond milk, which was fortified with calcium. Osteoid: Osteoblasts secrete osteoid, the unmineralized portion of the bone matrix, as the first step in their bone building process. J Clin Endocrinol Metab. If you would like to stop taking Strontium Boost until youre feeling better, there is no need to taper off. A comparison of adverse event and fracture efficacy data for strontium ranelate in regulatory documents and the publication record. You could try soy yogurt instead. While AlgaeCal Plus and Strontium Boost alone are clinically supported to increase bone mineral density, the mediation youve mentioned will likely be safe and beneficial to your efforts as long as the form youre taking is bio-identical, and youre properly monitoring how youre metabolizing your estrogens. Hello! Re being insurance poor I am hoping that Dr. Grout will still be able to be helpful. If SCW took calcium (or ate foods rich in calcium) when she took her strontium, the calcium would have prevented strontiums absorption. Every woman in my family whom I know about for many generations back died from osteoporosis I am the poster child for risk for this disease, but have managed to beat it by learning what my bones need and supplying it. Most of the recent research on strontium has been done on strontium ranelate because it is patentable by a drug company since it is a combination of strontium plus ranelic acid a molecule never before seen on planet Earth and therefore patentable. You are so lucky to live there! Is a direct quotation from Lis thesis paper cited above on page 41 of the document or page 59 in the PDF format, if you just scroll down to page 41 or type in page 59 or search more effective than you will find it. Hi Lara, Note that the COMB study was conducted by Dr. GenUIs (not Genius)I have contacted his office regarding the type of exercise that was used by patients in the study and was surprised to learn that he recommends jumping, running, or jogging (exercises that are typically contraindicated for osteoporotic patients), working up to 300 repetitions. But now, after my in-depth review of the current research on strontium which involved reading more than 70 recently published papers in the peer-reviewed medical literature I am convinced that strontium citrate has so much to offer that will help ensure my bones remain healthy that Ive begun supplementing with Strontium Boost again! I have Your Bones on my Kindle now so I am reading (but must admit at my age I do forget rather quickly so sometimes need to re-read..) How did your DEXA tests turn out after being on AlgaeCal? Ive written quite a bit about BHRT (which I am on and have been on for more than 10 years now) you can read many these articles on Smart Publications website. Get visible results via a DEXA scan. Saying that those taking strontium ranelate had a relative risk for VTE of 1.4 compared to placebo means that strontium ranelate increased risk for VTE by 40%. Hope your DXA results are stellar keep me posted, Lara, Lara: I take a PPI for stomach ulcers which is time release and works for 24 hours. It is an issue for individuals with chronic kidney disease. MK-4 requires 15 milligrams 3x daily for efficacy. What do you recommend for me age 74 with fine bonesand osteoporosis with the above BMD results? Hi John, Calcium dosage in AlgaeCal Plus is actually 2x 360 or 720 mg/day as recommended daily dose of this supplement is 2 capsules, twice daily. Try to follow a plant based diet, not so easy to learn!! I observed three types of strontium salts and side effects of strontium supplements like nausea and headache etc. Dr. Wright recently commented to me that he thinks it best to start out with 680 mg of strontium citrate daily, but then to drop down to half this dosage or even a bit less once good results have been achieved. And more strontium in your bone causes the DEXA to overstate your bone density increase. Im now not certain where youre getting your information, but great Can this be whats going on? A total of 48 drugs were selected for oral bioavailability comparison. In men, a small loss is detected in 40-year olds, which increases to a loss of about -0.8% per year into old age. I take a Progessive MultiVitamin for women over 50 three times a day as suggested. Novel strontium fortified calcium salt for enhancing bone formation As in vitro and in vivo large animal model study. I will check out the digestion issue. Getting adequate vitamin K2 is clearly important for maintaining bone strength but not everyone can afford to get K2 from supplements and getting adequate K2 from natural foods is not easy either. 3X better proliferation of Osteoblasts than CaCO3 and Ca Citrate. Now, hes outplaying men half his age (he just turned 70), no brace, no limp. I mightve read it too fast. Im 63 years old, too isnt is great how much fun it is to be all grown up now that we can stay strong and healthy! If there is a line not to cross and the studies prove that ones strontium levels continuously increase when supplementing, how do you determine when to stop strontium intake? Strontium ranelate in regulatory documents and the publication record Zustin J, et al osteoid. Indexes ( e.g insurance poor i am hoping that Dr. Grout will still be able to be ng/mL. Ranelate can increase bone formation as in vitro and in vivo large animal model study the. 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